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Total Synthesis of Phorboxazole A
Author(s) -
Williams David R.,
Kiryanov Andre A.,
Emde Ulrich,
Clark Michael P.,
Berliner Martin A.,
Reeves Jonathan T.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390322
Subject(s) - total synthesis , chemistry , stereochemistry
Asymmetric allylation reactions of stannyl‐derived allyldiazaborolanes, a stereoselective cationic cyclization reaction for the formation of the fully substituted C22–C26 tetrahydropyran, and the use of a Julia olefination for the incorporation of the sensitive C37–C46 dienyl system are key features of a highly convergent, stereocontrolled total synthesis of phorboxazole A (see structure).