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Interactions with Aromatic Rings in Chemical and Biological Recognition
Author(s) -
Meyer Emmanuel A.,
Castellano Ronald K.,
Diederich François
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390319
Subject(s) - molecular recognition , aromaticity , chemistry , relevance (law) , intermolecular force , biochemical engineering , computer science , nanotechnology , molecule , materials science , organic chemistry , engineering , political science , law
Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different approaches—biological studies, molecular recognition studies with artificial receptors, crystallographic database mining, gas‐phase studies, and theoretical calculations—are pursued to generate a profound understanding of the structural and energetic parameters of individual recognition modes involving aromatic rings. This review attempts to combine and summarize the knowledge gained from these investigations. The review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.