Time‐Controlled Desorption of Ultrathin Polymer Films Triggered by Enzymatic Degradation | Zendy

Serizawa Takeshi | Zendy; Yamaguchi Miyuki | Zendy; Akashi Mitsuru | Zendy

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Time‐Controlled Desorption of Ultrathin Polymer Films Triggered by Enzymatic Degradation

Author(s) -

Serizawa Takeshi,

Yamaguchi Miyuki,

Akashi Mitsuru

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390293

Subject(s) - degradation (telecommunications) , desorption , polymer , chemical engineering , materials science , chemistry , polymer degradation , nanotechnology , organic chemistry , adsorption , computer science , telecommunications , engineering

Degrading films : Surface‐component‐dependent and time‐controlled degradation of a layer‐by‐layer (LbL) assembly comprising DNA and a cationic synthetic polymer is demonstrated through enzymatic hydrolysis by DNase I (see picture). The negatively charged enzyme is preserved on the cationic polymer surface in an inactive state, and changes in the concentrations of the essential Mg 2+ and Ca 2+ ions are used to control the activity of the enzyme, and thus control the desorption of the assembly.

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