Proline‐Catalyzed Asymmetric α‐Amination of Aldehydes and Ketones—An Astonishingly Simple Access to Optically Active α‐Hydrazino Carbonyl Compounds | Zendy

Duthaler Rudolf O. | Zendy

Premium

Proline‐Catalyzed Asymmetric α‐Amination of Aldehydes and Ketones—An Astonishingly Simple Access to Optically Active α‐Hydrazino Carbonyl Compounds

Author(s) -

Duthaler Rudolf O.

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390283

Subject(s) - enantioselective synthesis , amination , chemistry , catalysis , proline , dichloromethane , substrate (aquarium) , organic chemistry , keto–enol tautomerism , reductive amination , combinatorial chemistry , amino acid , biochemistry , oceanography , solvent , geology

Simple, direct, and highly enantioselective α‐amination of carbonyl compounds 1 with azodicarboxylates 2 no longer requires prior enolization of the substrate. The “magic” small‐organic‐molecule catalyst for this reaction in dichloromethane at room temperature is once again L ‐proline ( 3 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research