Premium
Cover Picture: Molecular Mousetraps: Gas‐Phase Studies of the Covalent Coupling of Noncovalent Complexes Initiated by Reactive Carbenes Formed by Controlled Activation of Diazo Precursors (Angew. Chem. Int. Ed. 9/2003)
Author(s) -
Julian Ryan R.,
May Jeremy A.,
Stoltz Brian M.,
Beauchamp J. L.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390276
Subject(s) - diazo , covalent bond , crown ether , non covalent interactions , chemistry , protonation , amine gas treating , molecule , functional group , reactive intermediate , gas phase , cover (algebra) , ether , stereochemistry , combinatorial chemistry , organic chemistry , hydrogen bond , catalysis , ion , polymer , mechanical engineering , engineering
Molecular mousetraps are an unprecedented class of host–guest reagents. In the example shown in the cover picture, 18‐crown‐6 ether is utilized as the “bait” to attract target molecules with a protonated primary amine functional group. Appropriate activation of the noncovalent complex springs the diazo “trap”, which leads to covalent attachment of the two molecules depicted in the reaction scheme. The research is detailed in the Communication by J. L. Beauchamp, B. M. Stoltz et al. on page 1012 ff.