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A Versatile Catalyst for the Sonogashira Coupling of Aryl Chlorides
Author(s) -
Köllhofer Axel,
Pullmann Thomas,
Plenio Herbert
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390273
Subject(s) - sonogashira coupling , aryl , catalysis , combinatorial chemistry , coupling (piping) , chemistry , organic chemistry , palladium , materials science , composite material , alkyl
Aryl chlorides are suitable substrates for the Sonogashira coupling! By using the versatile catalyst system Na 2 [PdCl 4 ]/PR 3 /CuI (PR 3 =(1‐Ad) 2 PBn, P t Bu 3 ), the Sonogashira coupling [Eq. (a)] of aryl chlorides with alkynes generates excellent yields of the corresponding disubstituted aryl alkynes.