A General Oxidative Cyclization of 1,5‐Dienes Using Catalytic Osmium Tetroxide | Zendy

Donohoe Timothy J. | Zendy; Butterworth Sam | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A General Oxidative Cyclization of 1,5‐Dienes Using Catalytic Osmium Tetroxide

Author(s) -

Donohoe Timothy J.,

Butterworth Sam

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390253

Subject(s) - dihydroxylation , osmium tetroxide , diastereomer , stereoselectivity , chemistry , oxidative phosphorylation , osmium , catalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , biochemistry , ruthenium , physics , electron microscope , optics

Dihydroxylation of 1,5‐dienes under acidic conditions is sufficient to induce an efficient oxidative cyclization that produces stereochemically defined tetrahydrofurans in one step [Eq. (1)]. This method is very general and efficient for a range of dienes and shows complete stereoselectivity for formation of the 2,5‐ cis diastereoisomers. Bn=benzyl, CSA=camphorsulfonic acid.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research