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Phospholane–Oxazoline Ligands for Ir‐Catalyzed Asymmetric Hydrogenation
Author(s) -
Tang Wenjun,
Wang Weimin,
Zhang Xumu
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390251
Subject(s) - oxazoline , catalysis , chemistry , class (philosophy) , scheme (mathematics) , asymmetric hydrogenation , combinatorial chemistry , organic chemistry , computer science , enantioselective synthesis , mathematics , mathematical analysis , artificial intelligence
A new class of chiral phospholane–oxazoline ligands P* was developed for Ir‐catalyzed asymmetric hydrogenation (see scheme, e.g. R=Ph; Ar= m ‐CH 3 C 6 H 4 ). High enantioselectivities (up to 99 % ee ) were obtained for the hydrogenation of methylstilbene derivatives and ( E )‐β‐methylcinnamic esters.
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