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Preparation and Asymmetric Hydrogenation of β‐Aryl‐Substituted β‐Acylaminoacrylates
Author(s) -
You Jingsong,
Drexler HansJoachim,
Zhang Songlin,
Fischer Christine,
Heller Detlef
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390242
Subject(s) - norbornadiene , aryl , catalysis , ferrocene , chemistry , asymmetric hydrogenation , substrate (aquarium) , function (biology) , enantioselective synthesis , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl , oceanography , electrode , evolutionary biology , geology , electrochemistry , biology
The Rh‐catalyzed asymmetric hydrogenation of β‐aryl‐substituted ( E )‐β‐acylaminoacrylates, which were isolated for the first time, with, for example [Rh{( R,R )‐(Et‐FerroTANE)}(nbd)] + as catalyst (see picture) proceeds under very mild conditions (25 °C, normal pressure) and high substrate/catalyst ratios with very good enantioselectivity (Et‐FerroTANE=(+)‐1,1′‐bis(2,4‐diethylphosphyltane)ferrocene, nbd=3,5‐norbornadiene).