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A New Principle in Combinatorial Asymmetric Transition‐Metal Catalysis: Mixtures of Chiral Monodentate P Ligands
Author(s) -
Reetz Manfred T.,
Sell Thorsten,
Meiswinkel Andreas,
Mehler Gerlinde
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390209
Subject(s) - denticity , transition metal , catalysis , enantioselective synthesis , chemistry , metal , combinatorial chemistry , computational chemistry , stereochemistry , organic chemistry
The right mix! : Surprisingly, the use of the mixture of two different chiral monodentate phosphorus ligands (e.g., a phosphonite/phosphite combination; see schematic representation; cod=1,5‐cyclooctadiene) in Rh‐catalyzed olefin hydrogenation leads to significantly higher enantioselectivities than in the case of the pure ligands themselves.