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New Catalyzed Three‐Component Cycloadditions for the Synthesis of Eight‐Membered Carbocycles
Author(s) -
Murakami Masahiro
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390200
Subject(s) - cycloaddition , component (thermodynamics) , catalysis , rhodium , atom (system on chip) , atom economy , chemistry , stereochemistry , combinatorial chemistry , computer science , organic chemistry , physics , parallel computing , thermodynamics
The sum always amounts to eight —Two new three‐component [ m + n + o ] cycloadditions offer novel synthetic routes to eight‐membered carbocycles (see scheme; m, n, o =4, 2, 2 or 5, 2, 1). The rhodium center serves as a template and brings three components into the necessary arrangement for the desired cycloaddition, thus enabling difficult‐to‐form eight‐membered carbocyclic rings to be constructed in a single chemical operation with good atom economy.