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The Preparation of a Double Metallahelicate Containing 28 Copper Atoms
Author(s) -
Johnson James A.,
Kampf Jeff W.,
Pecoraro Vincent L.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390157
Subject(s) - enantiopure drug , norvaline , copper , chemistry , chloride , metal , ion , metal ions in aqueous solution , stereochemistry , polymer chemistry , crystallography , combinatorial chemistry , organic chemistry , amino acid , enantioselective synthesis , catalysis , biochemistry , leucine
Both L ‐ or D ‐norvaline hydroxamic acids undergo one‐step reactions with acetate, chloride, and Cu II ions to form self‐assembled metallahelicates that contain 20 chiral carbon and four chiral metal centers. Enantiopure complexes of over three nanometers in length, and composed of either P ‐ or M ‐type double‐stranded helical oligomers (see scheme), have been isolated.