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Sliding Helix and Change of Coordination Geometry in a Model Di‐Mn II Protein
Author(s) -
DeGrado William F.,
Di Costanzo Luigi,
Geremia Silvano,
Lombardi Angela,
Pavone Vincenzo,
Randaccio Lucio
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390127
Subject(s) - geometry , helix (gastropod) , crystallography , coordination geometry , chemistry , physics , mathematics , geology , paleontology , molecule , hydrogen bond , organic chemistry , snail
An artificial four‐helix‐bundle metalloprotein was shown to have two different dimanganese coordination environments with bridging or terminal solvent molecules. A sliding‐helix mechanism, by which metalloproteins can accommodate changes in their coordination environment, is demonstrated (see picture).