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Thioglycoligases: Mutant Glycosidases for Thioglycoside Synthesis
Author(s) -
Jahn Michael,
Marles Jennifer,
Warren R. Antony J.,
Withers Stephen G.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390114
Subject(s) - mutant , chemistry , computational biology , stereochemistry , computer science , biology , biochemistry , gene
Engineering of the active site of retaining glycosidases in conjunction with the appropriate modification of their substrates has led to the enzymatic synthesis of thioglycosidic linkages in thiooligosaccharides (see scheme).