Premium
Nucleotide Cross‐Linking Induced by Photoreactions of Platinum( IV )–Azide Complexes
Author(s) -
Müller Philippe,
Schröder Björn,
Parkinson John A.,
Kratochwil Nicole A.,
Coxall Robert A.,
Parkin Andrew,
Parsons Simon,
Sadler Peter J.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390110
Subject(s) - azide , bifunctional , chemistry , adduct , platinum , guanine , nucleotide , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , catalysis , gene
Visible light irradiation of inert [Pt IV (diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N 2 , and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells (see scheme).