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A Catalytic Approach to ( R )‐(+)‐Muscopyridine with Integrated “Self‐Clearance”
Author(s) -
Fürstner Alois,
Leitner Andreas
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390103
Subject(s) - biochemical engineering , metathesis , retrosynthetic analysis , chemistry , combinatorial chemistry , computer science , total synthesis , stereochemistry , organic chemistry , engineering , polymerization , polymer
The integration of various metal‐catalyzed reactions into a one‐pot processes opens an unprecedentedly short and efficient route to the odoriferous alkaloid ( R )‐(+)‐muscopyridine. Importantly, it is shown how metathesis can be used for a most convenient “self‐clearance” of a product mixture (see scheme; OTf=CF 3 SO 3 ).
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