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Analogues of Neuropeptide Y Containing β‐Aminocyclopropane Carboxylic Acids are the Shortest Linear Peptides That Are Selective for the Y 1 Receptor
Author(s) -
Koglin Norman,
Zorn Chiara,
Beumer Raphael,
Cabrele Chiara,
Bubert Christian,
Sewald Norbert,
Reiser Oliver,
BeckSickinger Annette G.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390078
Subject(s) - chemistry , stereochemistry , amino acid , carboxylic acid , receptor , 1 aminocyclopropane 1 carboxylic acid , neuropeptide y receptor , neuropeptide , enzyme , biochemistry , biosynthesis
Unique, conformationally restricted β‐amino acids are a constituent of truncated linear peptides such as 1 , which have been obtained for the first time; these species show high and selective affinity toward the Y 1 receptor. The high affinity of these ligands is dependent on the position and the configuration of this β‐aminocyclopropane carboxylic acid.