Towards Multistep Nanostructure Synthesis: Programmed Enzymatic Self‐Assembly of DNA/Gold Systems | Zendy

Kanaras Antonios G. | Zendy; Wang Zhenxin | Zendy; Bates Andrew D. | Zendy; Cosstick Richard | Zendy; Brust Mathias | Zendy

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Towards Multistep Nanostructure Synthesis: Programmed Enzymatic Self‐Assembly of DNA/Gold Systems

Author(s) -

Kanaras Antonios G.,

Wang Zhenxin,

Bates Andrew D.,

Cosstick Richard,

Brust Mathias

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390075

Subject(s) - dna , dna ligase , restriction enzyme , nanostructure , nanotechnology , colloidal gold , enzyme , chemistry , materials science , biophysics , biochemistry , biology , nanoparticle

Enzyme‐dependent assembly of DNA/gold nanostructures is achieved using DNA‐capped gold colloids and DNA processing enzymes. Particle‐bound DNA double strands are cleaved at designated sites by a restriction endonuclease (see picture). In a subsequent step the particles are linked to each other through these activated sites by a DNA ligase. This new strategy enables the multistep synthesis of nanostructures.

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