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Asymmetric Catalytic Aza‐Henry Reactions Leading to 1,2‐Diamines and 1,2‐Diaminocarboxylic Acids
Author(s) -
Westermann Bernhard
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390071
Subject(s) - mannich reaction , aldol reaction , nitroaldol reaction , chemistry , catalysis , nitro , amine gas treating , organic chemistry , aka , enantioselective synthesis , medicinal chemistry , combinatorial chemistry , computer science , alkyl , library science
In the wake of the aldol and Mannich reactions , textbook examples of asymmetric reactions, comes the aza‐Henry reaction (aka nitro‐Mannich reaction), which leads to 1,2‐diamines or α,β‐diaminocarboxylic acids (see scheme, PG=protecting group). Recent developments point to a bright future for this transformation.