Asymmetric Catalytic Aza‐Henry Reactions Leading to 1,2‐Diamines and 1,2‐Diaminocarboxylic Acids | Zendy

Westermann Bernhard | Zendy

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Asymmetric Catalytic Aza‐Henry Reactions Leading to 1,2‐Diamines and 1,2‐Diaminocarboxylic Acids

Author(s) -

Westermann Bernhard

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390071

Subject(s) - mannich reaction , aldol reaction , nitroaldol reaction , chemistry , catalysis , nitro , amine gas treating , organic chemistry , aka , enantioselective synthesis , medicinal chemistry , combinatorial chemistry , computer science , alkyl , library science

In the wake of the aldol and Mannich reactions , textbook examples of asymmetric reactions, comes the aza‐Henry reaction (aka nitro‐Mannich reaction), which leads to 1,2‐diamines or α,β‐diaminocarboxylic acids (see scheme, PG=protecting group). Recent developments point to a bright future for this transformation.

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