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Iridium‐Catalyzed Mizoroki–Heck‐Type Reaction of Organosilicon Reagents
Author(s) -
Koike Tooru,
Du Xiaoli,
Sanada Tomoyuki,
Danda Yasuaki,
Mori Atsunori
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390061
Subject(s) - organosilicon , iridium , catalysis , reagent , chemistry , rhodium , substrate (aquarium) , organic chemistry , solvent , medicinal chemistry , oceanography , geology
Independent of substrate and solvent , the CC bond‐forming reaction of organosilicon reagents with α,β‐unsaturated carbonyl compounds can be catalyzed by an iridium complex to give exclusively the Mizoroki–Heck‐type addition/elimination product (see scheme). This result sharply contrasts the analogous reaction with a rhodium catalyst under similar conditions in which the 1,4‐addition product is obtained preferentially. cod=cycloocta‐1,5‐diene.
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