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Thin‐Chip Microspray System for High‐Performance Fourier‐Transform Ion‐Cyclotron Resonance Mass Spectrometry of Biopolymers
Author(s) -
Rossier Joël S.,
Youhnovski Nikolay,
Lion Niels,
Damoc Eugen,
Becker Susanne,
Reymond Frédéric,
Girault Hubert H.,
Przybylski Michael
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390050
Subject(s) - fourier transform ion cyclotron resonance , mass spectrometry , ion cyclotron resonance , posttranslational modification , proteomics , fourier transform , analytical chemistry (journal) , chemistry , cyclotron resonance , top down proteomics , cyclotron , protein mass spectrometry , materials science , ion , chromatography , physics , tandem mass spectrometry , biochemistry , organic chemistry , quantum mechanics , gene , enzyme
Microchip innovation : A thin‐film microchip system has been developed for microelectrospray Fourier‐transform ion‐cyclotron resonance mass spectrometry. Application perspectives include the analysis of combinatorial libraries and high‐performance proteomics (as shown for the peptide fragment of the phosphorylation domain (512–538) of human neurofibrillary tau protein; the seven phosphorylation sites are indicated in red).