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A Diversity‐Oriented Synthesis of α‐Amino Acid Derivatives by a Silyltelluride‐Mediated Radical Coupling Reaction of Imines and Isonitriles
Author(s) -
Yamago Shigeru,
Miyazoe Hiroshi,
Nakayama Takeyoshi,
Miyoshi Masaki,
Yoshida Junichi
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390039
Subject(s) - imine , chemistry , coupling (piping) , amino acid , combinatorial chemistry , coupling reaction , organic chemistry , computational chemistry , catalysis , biochemistry , materials science , metallurgy
A radical idea : A diversity‐oriented synthesis of α‐amino acid derivatives is realized by the silyltelluride‐mediated radical coupling of imines and isonitriles followed by various transformations of the carbon–tellurium bond of the coupling products (see scheme). The α‐amino radical generated from the imine and the silyltelluride is the key intermediate in the coupling reaction.