A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution | Zendy

TissotCroset Karine | Zendy; Polet Damien | Zendy; Alexakis Alexandre | Zendy

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A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution

Author(s) -

TissotCroset Karine,

Polet Damien,

Alexakis Alexandre

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200353744

Subject(s) - phosphoramidite , allylic rearrangement , ligand (biochemistry) , chemistry , substitution (logic) , combinatorial chemistry , amination , reagent , iridium , tsuji–trost reaction , catalysis , computer science , organic chemistry , programming language , dna , biochemistry , receptor , oligonucleotide

Very high enantioselectivity has been achieved both in the copper‐catalyzed alkylation of allylic substrates by Grignard and organozinc reagents and in the iridium‐catalyzed amination of cinnamyl carbonate by employing a very efficient phosphoramidite ligand (see scheme).

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