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A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution
Author(s) -
TissotCroset Karine,
Polet Damien,
Alexakis Alexandre
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353744
Subject(s) - phosphoramidite , allylic rearrangement , ligand (biochemistry) , chemistry , substitution (logic) , combinatorial chemistry , amination , reagent , iridium , tsuji–trost reaction , catalysis , computer science , organic chemistry , programming language , dna , biochemistry , receptor , oligonucleotide
Very high enantioselectivity has been achieved both in the copper‐catalyzed alkylation of allylic substrates by Grignard and organozinc reagents and in the iridium‐catalyzed amination of cinnamyl carbonate by employing a very efficient phosphoramidite ligand (see scheme).