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Controlled Submolecular Translational Motion in Synthesis: A Mechanically Interlocking Auxiliary
Author(s) -
Hannam Jeffrey S.,
Lacy Stephen M.,
Leigh David A.,
Saiz Carlos G.,
Slawin Alexandra M. Z.,
Stitchell Sheila G.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353606
Subject(s) - interlocking , thread (computing) , cleavage (geology) , rotaxane , translational motion , simple (philosophy) , computer science , chemistry , physics , crystallography , materials science , engineering , mechanical engineering , classical mechanics , programming language , composite material , philosophy , supramolecular chemistry , fracture (geology) , crystal structure , epistemology
Sew simple: How can you put a molecular bead on a thread when no recognition elements exist between them? A mechanically interlocking auxiliary assembles the macrocycle around a template, controlled submolecular translation moves the ring over the desired substrate and, finally, cleavage of the auxiliary leaves an apparently “impossible” rotaxane (see scheme).