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Iterative Glycosylation of 2‐Deoxy‐2‐aminothioglycosides and Its Application to the Combinatorial Synthesis of Linear Oligoglucosamines
Author(s) -
Yamago Shigeru,
Yamada Takeshi,
Maruyama Tomokazu,
Yoshida Junichi
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353552
Subject(s) - glycosylation , scheme (mathematics) , glycosyl , combinatorial chemistry , coupling (piping) , chemistry , computer science , mathematics , stereochemistry , engineering , biochemistry , mathematical analysis , mechanical engineering
Highly efficient coupling is observed with thioglycosides, which act both as glycosyl donors and acceptors. The iteration of the glycoside‐coupling reaction under the same conditions allows the rapid assembly of a library of linear oligoglucosamines (see scheme; Phth=phthaloyl).