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A DNA‐Based Machine That Can Cyclically Bind and Release Thrombin
Author(s) -
Dittmer Wendy U.,
Reuter Andreas,
Simmel Friedrich C.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353537
Subject(s) - aptamer , thrombin , dna , guanine , blood clotting , ellipse , biophysics , molecular machine , chemistry , computational biology , nanotechnology , biology , microbiology and biotechnology , biochemistry , materials science , physics , engineering , gene , biomedical engineering , nucleotide , platelet , astronomy , immunology
A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release the human blood‐clotting factor α‐thrombin, depending on the operator DNA sequence addressing it. In the picture the aptamer structure, which assumes a conformation characterized by two stacked guanine quadruplex structures, is linked to thrombin (gray ellipse).