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A Double Ring‐Closing Metathesis Approach for the Synthesis of β‐ C ‐Trisaccharides
Author(s) -
Postema Maarten H. D.,
Piper Jared L.,
Komanduri Venu,
Liu Lei
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353478
Subject(s) - olefin metathesis , ring closing metathesis , double bond , enol , metathesis , closing (real estate) , yield (engineering) , olefin fiber , chemistry , ring (chemistry) , combinatorial chemistry , organic chemistry , materials science , political science , catalysis , law , metallurgy , polymerization , polymer
Good things come in threes : A variety of β‐ C ‐trisaccharides have been successfully synthesized by double ring‐closing metathesis, which provides the products in excellent overall yield after functionalization of the newly formed double bonds (see scheme). The precursor olefin–enol ethers were prepared by Takai methylenation of the appropriate diesters.