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Left‐Handed Helical Twists in “Mixed β‐Peptides” Derived From Alternating C‐Linked Carbo‐β 3 ‐Amino Acids and β‐hGly Units
Author(s) -
Sharma Gangavaram V. M.,
Reddy Kondreddi Ravinder,
Krishna Palakodety Radha,
Sankar Ampapathi Ravi,
Jayaprakash Pagadala,
Jagannadh Bulusu,
Kunwar Ajit C.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353467
Subject(s) - amino acid , left handed , peptide , chemistry , stereochemistry , crystallography , physics , biochemistry , optics
Ambidextrous peptides : Novel mixed β‐peptides were synthesized from alternating C‐linked carbo‐β 3 ‐amino acid and β‐homoglycine residues. The peptides form unprecedented left‐handed 10/12 and 12/10 helices (see picture) in addition to the corresponding right‐handed helices.