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Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina
Author(s) -
Yamaguchi Kazuya,
Matsushita Mitsunori,
Mizuno Noritaka
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353461
Subject(s) - ruthenium , acrylonitrile , catalysis , yield (engineering) , selectivity , acrylamide , chemistry , hydroxide , nitrile , organic chemistry , combinatorial chemistry , materials science , polymer , copolymer , metallurgy
A broad range of amides is accessible in excellent yield (>99 %) by hydration of the corresponding nitriles in water in the presence of the supported ruthenium catalyst Ru(OH) x /Al 2 O 3 (see scheme). For example, the industrially important conversion of acrylonitrile into acrylamide was achieved in quantitative yield and better than 99 % selectivity. The catalyst can be reused without loss of catalytic activity and selectivity.