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Efficient, Copper‐Catalyzed, Aerobic Oxidation of Primary Alcohols
Author(s) -
Markó István E.,
Gautier Arnaud,
Dumeunier Raphaël,
Doda Kanae,
Philippart Freddi,
Brown Stephen M.,
Urch Christopher J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353458
Subject(s) - primary (astronomy) , alcohol oxidation , catalysis , chemistry , copper , organic chemistry , combinatorial chemistry , physics , astronomy
An additive is the key to success : Catalytic amounts of N ‐methylimidazole are crucial for the aerobic oxidation of primary aliphatic alcohols in the presence of CuCl, 1,10‐phenanthroline (phen), and di‐ tert ‐butyl azodicarboxylate (DBAD). This reaction, under neutral conditions, yields the aldehydes quantitatively and selectively without overoxidation to the carboxylic acids.