Small‐Interfering‐RNA Expression in Cells Based on an Efficiently Constructed Dumbbell‐Shaped DNA | Zendy

Taki Masumi | Zendy; Kato Yoshio | Zendy; Miyagishi Makoto | Zendy; Takagi Yasuomi | Zendy; Taira Kazunari | Zendy

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Small‐Interfering‐RNA Expression in Cells Based on an Efficiently Constructed Dumbbell‐Shaped DNA

Author(s) -

Taki Masumi,

Kato Yoshio,

Miyagishi Makoto,

Takagi Yasuomi,

Taira Kazunari

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200353445

Subject(s) - dumbbell , rna , dna , rna interference , small interfering rna , computational biology , vector (molecular biology) , gene , coding (social sciences) , physics , computer science , biology , microbiology and biotechnology , genetics , mathematics , recombinant dna , physiology , statistics

A dumbbell‐shaped DNA , expected to be useful for gene therapy, was synthesized by using a novel method. The dumbbell‐shaped vector (see picture) contains a small interfering RNA (siRNA) coding sequence, and the vector was used to investigate the RNA interference (RNAi) effect inside cells.

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