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An Efficient and General Method for the Synthesis of α,ω‐Difunctional Reduced Polypropionates by Zr‐Catalyzed Asymmetric Carboalumination: Synthesis of the Scyphostatin Side Chain
Author(s) -
Tan Ze,
Negishi Eiichi
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353429
Subject(s) - side chain , catalysis , enantioselective synthesis , chemistry , combinatorial chemistry , chain (unit) , polymer chemistry , organic chemistry , physics , polymer , astronomy
A decrease in the number of linear synthetic steps and an increase in efficiency have been realized in the synthesis of the side chain of scyphostatin. An efficient and selective synthesis of α,ω‐difunctional reduced polypropionates from methyl 3‐hydroxy‐2‐methylpropionate through the use of a Zr‐catalyzed asymmetric carboalumination has been developed (see scheme, TBS= tert ‐butyldimethylsilyl).