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Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System
Author(s) -
Runyon Matthew K.,
JohnsonKerner Bethany L.,
Ismagilov Rustem F.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353428
Subject(s) - hemostasis , microfluidics , biomedical engineering , nanotechnology , materials science , medicine , surgery
The proof of the model is in the function : A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.