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Remarkable 4,4′‐Substituent Effects on Binap: Highly Enantioselective Ru Catalysts for Asymmetric Hydrogenation of β‐Aryl Ketoesters and Their Immobilization in Room‐Temperature Ionic Liquids
Author(s) -
Hu Aiguo,
Ngo Helen L.,
Lin Wenbin
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353415
Subject(s) - enantioselective synthesis , substituent , steric effects , ionic liquid , aryl , catalysis , chemistry , asymmetric hydrogenation , binap , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
A family of chiral diphosphanes with systematically tunable electronic and steric properties have been used in the asymmetric hydrogenation of β‐aryl ketoesters with excellent ee values (up to 99.8 %) by taking advantage of remarkable 4,4′‐substituent effects on binap. These highly enantioselective Ru catalysts have also been effectively immobilized in room‐temperature ionic liquids (RTIL).