Premium
Total Synthesis and Stereochemical Assignment of Myriaporones 1, 3, and 4
Author(s) -
Fleming Kristen N.,
Taylor Richard E.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353348
Subject(s) - stereocenter , stereoselectivity , aldol reaction , nitrile , total synthesis , stereochemistry , cycloaddition , computer science , chemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , catalysis
Two stereoselective aldol reactions , a nitrile oxide cycloaddition, and a stereoselective late‐stage epoxidation were key steps in the total synthesis of myriaporones 1, 3, and 4 (see scheme). The synthesis allowed the unambiguous assignment of stereogenic centers not previously assigned for these compounds.