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Total Synthesis of Natural Myriaporones
Author(s) -
Pérez Marta,
del Pozo Carlos,
Reyes Fernando,
Rodríguez Alberto,
Francesch Andrés,
Echavarren Antonio M.,
Cuevas Carmen
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353313
Subject(s) - aldol reaction , total synthesis , aldehyde , amide , content (measure theory) , stereochemistry , chemistry , computer science , combinatorial chemistry , organic chemistry , mathematics , catalysis , mathematical analysis
The relative and absolute configuration of the cytotoxic myriaporones (e.g. 4 ) was assigned by their total synthesis from aldehyde 1 . Key steps included aldol reactions with chiral oxazolidinone 2 and with Weinreb amide 3 . TBS= tert ‐butyldimethylsilyl, PMB= p‐ methoxybenzyl.