A Peptidomimetic HIV‐Entry Inhibitor Directed against the CD4 Binding Site of the Viral Glycoprotein gp120 | Zendy

Neffe Axel T. | Zendy; Meyer Bernd | Zendy

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A Peptidomimetic HIV‐Entry Inhibitor Directed against the CD4 Binding Site of the Viral Glycoprotein gp120

Author(s) -

Neffe Axel T.,

Meyer Bernd

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200353271

Subject(s) - peptidomimetic , glycoprotein , peptide , chemistry , human immunodeficiency virus (hiv) , entry inhibitor , binding site , stereochemistry , virology , biochemistry , biology , viral entry , virus , viral replication

Barring infection : A new CD4‐binding peptidomimetic (see ball‐and‐stick structure; CD4 is shown in green) has been designed and synthesized as an entry inhibitor of the HIV virus. The binding affinity of the peptidomimetic for CD4 is 40 μ M , which is 150‐fold better than that of the lead peptide NMWQKVGTPL. The mimetic also has a lower molecular weight and a higher proteolytic stability than the lead peptide.

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