Premium
Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV‐Induced Lesion
Author(s) -
Giese Bernd,
Carl Barbara,
Carl Thomas,
Carell Thomas,
Behrens Christoph,
Hennecke Ulrich,
Schiemann Olav,
Feresin Emiliano
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353264
Subject(s) - thymine , pyrimidine dimer , dna , electron transfer , electron , electron transport chain , chemistry , nucleoside , lesion , photochemistry , materials science , dna damage , stereochemistry , biochemistry , physics , medicine , quantum mechanics , psychiatry
Site‐selective injection of a single electron into thymine (yellow) through the modified nucleoside 1 ( 1 → 2 ) was used to examine the dependence of excess electron transfer in DNA on distance. The DNA was cleaved upon arrival of the electron at a thymine dimer (red). This assay showed that one electron can repair more than one UV‐induced lesion in DNA 3 .