Premium
Aminoglycoside Microarrays To Study Antibiotic Resistance
Author(s) -
Disney Matthew D.,
Magnet Sophie,
Blanchard John S.,
Seeberger Peter H.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353236
Subject(s) - antibiotics , aminoglycoside , dna microarray , computational biology , antibiotic resistance , chemistry , enzyme , microarray , microbiology and biotechnology , biochemistry , biology , gene , gene expression
On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance‐causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.