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Dimeric Aminoglycosides as Antibiotics
Author(s) -
Agnelli Fabio,
Sucheck Steven J.,
Marby Kenneth A.,
Rabuka David,
Yao SuLan,
Sears Pamela S.,
Liang FuSen,
Wong ChiHuey
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353225
Subject(s) - aminoglycoside , antibiotics , ribosomal rna , rna , chemistry , microbiology and biotechnology , biology , biochemistry , gene
Double duty : Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside‐resistant bacterial strains.