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Bioactive Protein Nanoarrays on Nickel Oxide Surfaces Formed by Dip‐Pen Nanolithography
Author(s) -
Nam JwaMin,
Han Sang Woo,
Lee KiBum,
Liu Xiaogang,
Ratner Mark A.,
Mirkin Chad A.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353203
Subject(s) - dip pen nanolithography , nanolithography , nanotechnology , nickel , substrate (aquarium) , atomic force microscopy , nickel oxide , oxide , materials science , chemistry , fabrication , metallurgy , biology , medicine , alternative medicine , pathology , ecology
Ink flowing from a pen : Direct‐write dip‐pen nanolithography of His‐tagged proteins (ubiquitin and thioredoxin) has been used to generate biologically active protein nanoarrays with feature sizes as small as 80 nm on nickel oxide surfaces without the need for an applied electric field. The protein molecules in this system seem to diffuse from the Ni‐coated atomic force microscopy (AFM) tips to the Ni‐coated substrate (see diagram).