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Synthesis and Biological Validation of a Ubiquitous Quorum‐Sensing Molecule
Author(s) -
Meijler Michael M.,
Hom Louis G.,
Kaufmann Gunnar F.,
McKenzie Kathleen M.,
Sun Chengzao,
Moss Jason A.,
Matsushita Masayuki,
Janda Kim D.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353150
Subject(s) - quorum sensing , enantiopure drug , bacteria , bioluminescence , chelation , chemistry , computer science , combinatorial chemistry , biofilm , biology , biochemistry , organic chemistry , enantioselective synthesis , genetics , catalysis
Chemical communication (“quorum sensing”) amongst bacteria has been studied by the synthesis and study of enantiopure ( R )‐4,5‐dihydroxy‐2,3‐pentanedione (DPD, see scheme). Bioactivity assays with DPD have shown that chelation of boron by the cyclic form of DPD appears to be essential for full induction of bioluminescence, which is an example of quorum‐sensing‐controlled behavior.