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Iron‐Containing Nucleoside Analogues with Pronounced Apoptosis‐Inducing Activity
Author(s) -
Schlawe Daniel,
Majdalani André,
Velcicky Juraj,
Heßler Erik,
Wieder Thomas,
Prokop Aram,
Schmalz HansGünther
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353132
Subject(s) - apoptosis , nucleoside , tumor cells , programmed cell death , chemistry , nucleoside analogue , apoptotic cell death , biochemistry , stereochemistry , cancer research , biology
Bioactive organometallic compounds: Iron‐containing nucleoside analogues, which can be stereoselectively synthesized in a few steps starting from simple carbohydrates, cause tumor cells to undergo apoptosis (programmed cell death; see picture for the typical morphological characteristics of BJAB tumor cells after apoptosis).