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Synthesis of the Furanosteroidal Antibiotic Viridin
Author(s) -
Anderson Edward A.,
Alexanian Erik J.,
Sorensen Erik J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353129
Subject(s) - domino , dihydroxylation , rhodium , alkyne , combinatorial chemistry , chemistry , electrocyclic reaction , stereochemistry , catalysis , organic chemistry , enantioselective synthesis , bicyclic molecule
A rhodium‐catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy‐directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin ( 1 ) from a simple acyclic triyne.
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