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Direct Proline‐Catalyzed Asymmetric α‐Aminoxylation of Ketones
Author(s) -
Hayashi Yujiro,
Yamaguchi Junichiro,
Sumiya Tatsunobu,
Shoji Mitsuru
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353085
Subject(s) - nitrosobenzene , enantioselective synthesis , proline , catalysis , yield (engineering) , chemistry , combinatorial chemistry , organic chemistry , amino acid , materials science , biochemistry , metallurgy
Nitrosobenzene is the oxygen source in the direct catalytic enantioselective α‐aminoxylation of ketones catalyzed by L ‐proline [Eq. (1)]. Versatile α‐aminoxylated ketones are obtained in high yield and with excellent enantioselectivities.