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Templated Ligand Assembly by Using G‐Quadruplex DNA and Dynamic Covalent Chemistry
Author(s) -
Whitney Andrew M.,
Ladame Sylvain,
Balasubramanian Shankar
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353069
Subject(s) - g quadruplex , dna , covalent bond , chemistry , surface plasmon resonance , ligand (biochemistry) , macromolecule , aptamer , dynamic covalent chemistry , combinatorial chemistry , dna nanotechnology , biophysics , disulfide bond , nanotechnology , biochemistry , materials science , molecule , biology , nanoparticle , microbiology and biotechnology , organic chemistry , receptor , supramolecular chemistry
Reversible disulfide chemistry is used to identify ligands that bind G‐quadruplex DNA from a small dynamic combinatorial library (DCL) (see scheme). The biological macromolecular target is shown to induce an equilibrium shift. Surface plasmon resonance demonstrates that the two amplified species bind the quadruplex DNA.