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Efficient Palladium‐Catalyzed Coupling of Aryl Chlorides and Tosylates with Terminal Alkynes: Use of a Copper Cocatalyst Inhibits the Reaction
Author(s) -
Gelman Dmitri,
Buchwald Stephen L.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353015
Subject(s) - aryl , catalysis , palladium , copper , terminal (telecommunication) , chemistry , coupling (piping) , coupling reaction , combinatorial chemistry , polymer chemistry , organic chemistry , materials science , metallurgy , computer science , telecommunications , alkyl
Less catalyst, lower temperature , and greater generality are the advantages of the new general protocol over those previously described for the palladium‐catalyzed coupling of aryl chlorides and alkynes (see scheme). Better results are obtained without a copper cocatalyst, which has been found to inhibit product formation in the coupling reaction of aryl chlorides with terminal alkynes.