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Direct Evidence for a Furtive State in the Degradation of Carbasalatum Calcicum
Author(s) -
Ochsenbein Philippe,
Bonin Michel,
Masson Olivier,
Loyaux Denis,
Chapuis Gervais,
Schenk Kurt J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353007
Subject(s) - degradation (telecommunications) , dissolution , nucleation , crystal structure , crystal (programming language) , chemistry , crystallography , synchrotron , materials science , physics , computer science , organic chemistry , optics , telecommunications , programming language
Blink and you will miss it! The structure of carbasalatum calcicum (CC) has been determined by synchrotron powder diffractometry. By scrutinizing crystal dissolution and nucleation, it was found that the degradation of CC in water involves acetylsalicylatum calcicum (AC) as a furtive species that quickly exchanges its acetylsalicylic acid (ASA) ligands with water (see scheme). The crystal structure of AC is also reported.