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Enantioselective H‐Atom Transfer Reactions: A New Methodology for the Synthesis of β 2 ‐Amino Acids
Author(s) -
Sibi Mukund P.,
Patil Kalyani
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200353000
Subject(s) - enantioselective synthesis , chemistry , enantiomer , amino acid , radical , atom (system on chip) , lewis acids and bases , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , computer science , biochemistry , parallel computing
A radical step : The addition of radicals to amino acrylates and subsequent H‐atom transfer in the presence of chiral Lewis acid activators provides β 2 ‐amino acids in high yields and enantiomeric purity (see scheme; Ln*=chiral ligands, Fmoc=9‐fluorenylmethoxycarbonyl).