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Porphyrin Traps Its Terminator! Concerted and Stepwise Porphyrin Degradation Mechanisms Induced by Heme‐Oxygenase and Cytochrome P450
Author(s) -
Sharma Pankaz K.,
Kevorkiants Rouslan,
de Visser Sam P.,
Kumar Devesh,
Shaik Sason
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352943
Subject(s) - porphyrin , heme , heme oxygenase , chemistry , oxygenase , enzyme , photochemistry , stereochemistry , biochemistry
Concerted or stepwise? A homolytic stepwise pathway is taken by the enzyme heme‐oxygenase (HO) to degrade the porphyrin ring in heme species. The porphyrin ring assists the enzyme by trapping the hydroxyl radical during the degradation (see scheme). HO is compared to cytochrome P450.